![]() In addition, immune cells can directly communicate with each other to attain temporally choreographed responses. Furthermore, the immune system can leverage specialized immune cell types to form consortia and perform distributed computing, where cells collectively address a challenge, with each cell type is tasked with sensing and producing a specific subset of inputs and outputs. For instance, T cells have complex biocomputation circuitries that can detect antigens and integrate signals from co-stimulatory and co-inhibitory receptors in response to pathogens or tumors. Our work highlights that a simple split CAR design can generate diverse and complex phenotypes and provide a foundation for engineering an immune cell consortium with user-defined functionalities.Ī remarkable feature of the human immune system is its exceptional ability to sense and logically respond to diverse antigens and environmental signals. We also create an inducible multi-cellular NIMPLY circuit, kill switch, and a synthetic intercellular communication channel. ![]() Here, leveraging our split, universal, and programmable (SUPRA) CAR system, we develop an inhibitory feature, achieving a three-input logic, and demonstrate that this programmable system is functional in diverse adaptive and innate immune cells. However, most CAR designs lack computation features and cannot reprogram multiple immune cell types in a coordinated manner. ![]() The ability to reprogram such an interconnected multicellular system holds enormous promise in treating various diseases, as exemplified by the use of chimeric antigen receptor (CAR) T cells as cancer therapy. ![]() The immune system is a sophisticated network of different cell types performing complex biocomputation at single-cell and consortium levels.
0 Comments
Leave a Reply. |